| Issue | Control variable | Scale |
| Climate change | CO2 concentration and radiative forcing | Global |
| Ocean acidification | Surface ocean CO32- saturation state | |
|
Stratospheric ozone depletion |
Ozone concentration |
|
| Perturbed biogeochemical flows |
Human-induced phosphorus inflow to ocean;
fixation of atmospheric N2 to bioavailable forms |
Regional |
| Atmospheric aerosol loading | Not quantified (regional particulate concentration proposed) | |
| Global freshwater use | Annual volume of water used in human activities | |
| Land system change |
Percent of Earth’s land converted to
cropland |
|
| Biodiversity loss | Global species extinction rate | Local |
| Chemical pollution | Not quantified (concentrations and effects considered) | |